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iranian journal of basic medical sciences

To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release.Materials and Methods Iranian Journal of Basic Medical Sciences. Globose basal stem cells were isolated from rat olfactory epithelium using GBC-III antibody and were characterized as multipotent stem cells using various neural progenitor markers. Objective(s) Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore complex that plays a role in the PT. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. CC BY-NC 4.0 by Journal of Basic Research in Medical Sciences (JBRMS) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. There was a significant association between sensitivity to mite and polymorphism of C allele of T1 SNP (P=0.02). Neurological functional scores of mild hypothermia were significantly improved (P<0.05). Thirty-six Wistar rats were randomly divided into a normal group, a model group, a CG-V group (15 mg/kg), a CG-VI group (3 mg/kg), a CG-VII group (6 mg/kg) and a positive drug group (silibinin capsule, 8 mg/kg). Conclusion This is a short guide how to format citations and the bibliography in a manuscript for Iranian Journal of Basic Medical Sciences (IJBMS). Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, … ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Conclusion: Objectives: Four novel mutations that lead to an amino acid substitution and two mutations in mitochondrial tRNA have been informed in this study. All patients were graded according to the Pfirrmann criteria. With optimized wet agglomeration temperature, spherical, dense, and strong agglomerates can be obtained. Apoptotic index of model group was significantly higher than that of normal group, but indices of CG-V and CG-VII groups were significantly lower than that of model group. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. Image analysis software was used to determine the expressions of CD11a, CD11b, and CD11c integrins quantitatively. Our results showed that the LEPR Q223R polymorphism is associated with increased breast cancer risk as well as tumor grade in a sample of Iranian subjects. Materials and Methods: Experimental rats were fed with high fructose diet for 6 weeks and then were treated with Z. multiflora extract or a pioglitazone solution for 2 weeks. Extraction of DNA from Mycobacterium strains and DNA fingerprinting with IS-6110, PGRS and DR probe were performed by standard protocols. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. However, the specific isoform of NADPH oxidases that may predominantly contribute to these events remains to be clarified. The seroprevalence of anti-CagA IgG was in males 48.6% and in females 31.6%. The relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0.1, 0.2, and 0.4 mM) were examined on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n= 5) and 10 µM methacholine (group 2, n= 8). This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Objective(s): GSP have protective effects against hepatic tissue injury due to antioxidant properties. There was no association between asthmatic patients and polymorphisms of alleles, genotypes and haplotypes of the ADAM33 gene. The administration of MESA significantly (P< 0.05) decreased the CECs number compared to hypertensive groups. Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Moreover, it seems that males are more susceptible to infection with CagA-positive strains compared to females. 2- Control (C) group, administrated with distilled water via gavage. Inhibition of miR-103 could promote ischemic stroke angiogenesis and reduce infarction volume via enhancing VEGF, which provides a new target for the clinical treatment of ischemic stroke. In case group, animals received morphine sulfate 10 mg/kg.body weight intraperitoneally during 7 days before mating, gestational period (GD 0-21), 18 and 32 days after delivery in the experimental groups. Iranian journal of basic medical sciences 14 (4), 308, 2011. After peer-review by expert national and international reviewers, 15 % of submitted papers were accepted for publication. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Results: Enzymes digestion analysis, sequencing results showed that the target gene (1296 base pair) was inserted correctly into the recombinant vector. We addressed the hypothesis that porin interacts with other mitochondrial proteins after ischemic injury.Materials and Methods Journal ISSN: 2008-3866, Iranian Journal of Chemistry & Chemical Engineering-International English Edition, Iranian Journal of Environmental Health Science & Engineering, Iranian Journal of Allergy Asthma and Immunology, Bosnian Journal of Basic Medical Sciences, Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology, Journal of The Brazilian Chemical Society, Iranian Journal of Arthropod-Borne Diseases, Annual Review of Astronomy and Astrophysics. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. FIFTY PREGNANT WISTAR RATS WERE RANDOMLY DIVIDED INTO FIVE GROUPS: 1- nano-silver (N.S) group; 30 mg/kg of N.S treated via gavage. A. marmelos showed dose dependent improvement in spatial learning and memory parameters that swimming time (Escape Latency) in normal-control and A. marmelos-treated diabetic animals rats was significantly (P< 0.01) lower than diabetic-control, while swimming speed was significantly (P< 0.05) higher.Conclusion Down-regulating miR-103 with the miR-103 inhibitor enhanced VEGF, ameliorated the neurological scores, decreased infarct volume, and increased vascular density in rats after MCAO. The enzymatic region of hyaluronidase gene was detected by bioinformatics method. Materials and Methods: Comparison between patients and healthy subjects regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes in patients with PCAG (P=0.03). Objective(s): Conclusion: Morphine administration before and during pregnancy and during lactation period causes pyramidal neurons loss in 18 and 32 days old infant mice. However, the effects of other fractions were significantly lower than theophylline in both groups (p< 0.01 to p< 0.001). 22, No. Conclusion: ResultsIn group 1, all concentrations of theophylline, ethyl acetate fraction and two final concentrations of n-butanol fraction showed significant relaxant effects in comparison with saline (p< 0.05 to P< 0.001). Iranian Journal of Basic Medical Sciences ijbms.mums.ac.ir Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson's disease Majid Jadidi 1, Saeed Moghadas Biat 22, Hamid Reza Sameni , Manouchehr Safari *, Abbas Ali Vafaei 43, Laya Ghahari We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. In the present work, we focused on some bioactive aspects of it.Materials and MethodsIn the present work, the compound was purified from Prangos uloptera using TLC and its phytotoxic, antibacterial, antifungal, antioxidant and cytotoxic effects were evaluated by Lettuce assay, disc diffusion method, mycelia radial growth, DPPH and MTT assays, respectively.Results Our results revealed that oxypeucedanin exhibit considerable phytotoxic activity and might play an allelopathic role for plants. Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. ConclusionWe conclude that oxypeucedanin (found in some vegetables) can be considered as an antiproliferative agent. Iranian Journal of Basic Medical Sciences ijbms.mums.ac.ir CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance No antipathogenic and antioxidant activity were found for oxypeucedanin in this study. Iranian journal of basic medical sciences 16 (10), 1031, 2013. Edited by: Muzafer Mujic, MD, PhD and Semir Vranic, MD, PhD. 【Iranian Journal of Basic Medical Sciences】CiteScore Trend: Comments from Authors * All review process metrics, such as acceptance rate and review speed, are limited to our user-submitted manuscripts. Higher temperature of the system during agglomeration process favors the formation of more regular agglomerates with mechanically stronger and denser structure; this can be explained by the promotion effect of temperature on the agglomeration process. A number of AOs with a 2'-O-methyl oligoribonucleotide (2'-O-Me) backbone system were systematically tested in this cellular splicing assay. Bacopa monnieri (BM), a traditional ayurvedic medicine, is a well-known memory enhancer. In a cross-sectional and prospective study, 95 strains of M. tuberculosis isolates were selected for DNA fingerprinting. Aegle marmelos Corr. This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. Journal Abbreviation: IRAN J BASIC MED SCI. Results: Insulin and adiponectin levels were assayed by enzyme-linked immunosorbent assay (ELISA) method. The bacteria including pET32a-hylA (hylA is abbreviation of Streptococcus pyogenes hyaluronidase gene and hylA is abbreviation of Streptococcus pyogenes hyaluronidase protein) plasmids were induced by IPTG and analyzed by SDS-PAGE. The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. Animals were treated for 4 weeks by A. marmelos or normal saline. In group 2, all concentrations of theophylline, ethyl acetate and aqueous fractions showed concentration dependent relaxant effects compared to that of saline (p< 0.01 to P< 0.001). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Results It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population. This research work can be helpful in understanding the nature of these stem cells and utilising them in future as potent candidates for neuro-regenerative therapies. Besides, in OGD human umbilical vein endothelial cells (HUVECs), inhibition of miR-103 could promote the increase of tube length and the migration of cells. Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. Conclusion: Results: The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. Investigation of interaction of adenine nucleotide transposes (ANT) and cyclophilin-D with porin by Western blotting showed no proteins co-purified with porin from injured tissues.Conclusion The present study implies that there may not be interaction between porin, and ANT or cyclophilin-D, and if there is any, it is not maintained during the purification procedure. ISO 4 (Information and documentation – Rules for the abbreviation of title words and titles of publications) is an international standard, defining a uniform system for the abbreviation of serial publication titles. The XRD and DSC showed stable character of theophylline in the drug loaded microspheres. Results: The PCR method was used to amplify enzymatic region of hyaluronidase gene from chromosomal DNA of Streptococcus pyogenes. Journal Abbreviation: IRAN J BASIC MED SCI Objective(s): This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on pyramidal neurons of hippocampus in 18 and 32 day mice offspring. Materials and Methods: Objective(s): In addition, siBAK1 can reverse the pro-apoptosis function of miR-125a inhibitors in NPCs. It has been notified that ion channels' activities in cardiomyocytes are sensitive to the ATP level. Conclusion: Male Wistar rats were randomly divided into normal-control, diabetic-control, and A. marmelos-treated diabetic groups (100, 250 and 500 mg/kg, p.o.). Blood and tissue samples were collected for analysis at the end of two weeks. Expressions of FN, Smad3, IGFBPrP1 and TGF-β1 genes were detected by Western Blot and immunohistochemical assays. Among carbapenem resistant isolates, 100% carried blaOXA-51-like, 82.47% carried blaOXA-23-like, 55.67% carried blaOXA-58-like, 22.68% carried blaOXA-40-like and 14.43% had blaOXA-143-like resistance genes. Materials and Methods Results Prevention of ovarian I/R injury-related infertility in rats with induced diabetes is not through antioxidant activity. The expression levels of miR-103 and VEGF were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting. Objective(s)As an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. Objective(s)Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. miR-122 overexpression decreased cell viability and migration, and increased cell apoptosis in hypoxia- treated PC-12 cells, but miR-122 silencing led to the opposite results. Materials and Methods: 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. The number of TUNEL positive cells in the CA1, CA3, and DG fields of rat offspring hippocampus increased in N.S and N.S+G groups comparing to other ones, and also reduced significantly in N.S+G group comparing to N.S group ((¥) P< 0.01). We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Besides, there was a significant association between sensitivity to weeds and genotype GG of V4 SNP (P=0.05). The mean thickness of the stratum pyramidal layer was decreased in the treated groups in comparison with controls (P<0.05), whereas the mean thickness of the stratum oriens, stratum radiatum and stratum lacunosum-moleculare in CA1 field and stratum oriens, stratum lucidum, stratum radiatum and stratum lacunosum-moleculare in CA3 were significantly increased in morphine treated group in comparison with controls (P<0.05). Methanolic extract of S. atropurpurea is able to modulate total plasma nitrate/nitrite levels and diminish endothelial damage via increasing EPCs. The Journal is an editorially independent double-blinded peer reviewed online open access journal owned and published by Iran University of Medical Sciences and aims to be a publication of international repute for reporting current regional and international adventures in all aspects of the medicine. For this purpose, we used in vivo 4-vessel occlusion model of rat brain and porin purification method by hydroxyapatite column. Iranian Journal of Basic Medical Sciences (Print) Document Type: Journal / Magazine / Newspaper: ISSN: 2008-3874: OCLC Number: 1076664907: Other Titles: Iranian Journal of Basic Medical Sciences: Reviews. Materials and Methods: Materials and Methods ijbms.mums.ac.ir Iranian Journal of Basic Medical Sciences In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme Azizeh Asadzadeh 1, Hajar Sirous 2, Morteza Pourfarzam 2, Parichehreh Yaghmaei 1, Afshin Fassihi 3* 1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Thoracic epidural blockade reduced mPAP and serum level of TNF-α and increased cGMP. Significantly more FN, Smad3 and IGFBPrP1 were expressed in treatment groups than those in normal group. Melatonin, famotidine, mirtazapine, and thiamin pyrophosphate prevented a rise in oxidant parameters and a decrease in antioxidants in ovarian tissue exposed to I/R. Apoptosis was examined by TUNEL assay. Basic and Clinical Neuroscience (BCN) is an open-access journal, which is the official publication of Iran University of Medical Sciences and the Iranian Neuroscience Society. Data provided are for informational purposes only. The control animals received an equivalent volume of normal saline. The target protein was expressed in the Escherichia coli. After isolation of non- degenerative and degenerative nucleus pulposus cells (NPCs), the targeting relationship between miR-125a and BAK1 was verified by dual luciferase reporter gene assay. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). As mitochondrial oxidative stress is probably entailed in ATP production, a candidate modifier factor for the long QT syndrome (LQTS) could be mitochondrial DNA (mtDNA). The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, open access, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran .

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